Bodies in diseases

Important bodies in pathology in various diseases::
1. Councilman bodies - hepatitis, yellow fever

2. Gamma gandy bodies - congestive splenomegaly

3. Negri bodies - rabies

4. Lewy bodies - Parkinson's disease

5. Hirano bodies - Alzheimer's disease

6. Ferruginous bodies - asbestosis

7. Asteroid bodies - sarcoidosis, sporotrichosis

8. Schaumann bodies - sarcoidosis

9. Verrocay bodies - schwannoma

10. Call exner bodies - granulosa cell Tumor

11. Schiller duval bodies - endodemal sinus Tumor

12. Ascoff bodies - rheumatic fever

13. Civatte body - lichen planus

14. Creola bodies - bronchial asthma

15. Donovan bodies - lymphogranuloma venerum

16. Henderson Peterson bodies - molluscum contagiosum

17. Michaelis guttmann body - malakoplakia

18. Pick bodies - pick disease

19. Zebra bodies - metachromatic leucodystrophy

20. Barr body - inactivated X chromosome

21. Kamino bodies - spitz naevus, malignant melanoma

22. Lafora bodies - myoclonic epilepsy

23. Heinz bodies - G6PD deficiency

24. Howell jolly bodies - post splenectomy, ineffective erythropoieisis

25. Pappenheimer bodies - sideroblastic

Harlequin Ichthyosis

Harlequin Ichthyosis-
is a rare genetic skin disorder. Infants who are affected by this condition are born with thick, yellow and very hard skin. The skin has large, diamond shaped plates separated by deep fissures. The disorder affects shapes of all the organs.

Mutations in the ABCA12 gene cause the disease.
The ABCA12 protein plays a major role in transporting fats in cells that make up the outermost layer of skin. Severe mutations in the gene lead to absence or partial production of the ABCA12 protein.
This results in lack of lipid transport and as a result the skin development is affected by varying degrees according to the severity of the mutation.

For a baby to inherit this condition, both father and mother, should be carriers of the mutated ABCA12 gene. ( autosomal recessive pattern.)

And guys there is no cure..
The oldest person survived was 23 yer old female and is a mother of two kids. But still it is a fatal condition!

Medinotes :)

PORTAL VEIN

Portal vein is 6-8 cm in length

Occurs by confluence of superior mesentric vein and splenic vein

Runs posterior to common bile duct

Two venous communications between coronary and azygous veins give rise to varices

Approximately it supplies 75%blood flow to the liver

Ligament related to portal vein -hepatoduodenal

Valveless structure

Esophagogastric varices devolop if there is portal HTN

Inc portal pressure-liver damage and bleeding

Normal pressure-  3-5mmhg

PORTAL VEIN

medinotes :)

Practice labour

Braxton hicks contractions!

False labour , prodromal labour,practice labour

1.Sporadic conctration
2.sometimes starts from the from the 6th week of pregnancy
3.mostly felt at 2nd,3,triminster
4. Occurs due to tightning  of the uterine muscles (dehydration may be a cause as it causes spasam of the muscle)
5.not all mothers experince ot

Mednots :)

Hernia :)

inguinal hernia- the intestine or the bladder protrudes through the abdominal wall or into the inguinal canal in the groin. About 96% of all groin hernias are inguinal, and most occur in men because of a natural weakness in this area.

 incisional hernia, the intestine pushes through the abdominal wall at the site of previous abdominal surgery. This type is most common in elderly or overweight people who are inactive after abdominal surgery.

femoral hernia occurs when the intestine enters the canal carrying the femoral artery into the upper thigh. Femoral hernias are most common in women, especially those who are pregnant or obese.

 umbilical hernia, part of the small intestine passes through the abdominal wall near the navel. Common in newborns, it also commonly afflicts obese women or those who have had many children.

hiatus hernia happens when the upper stomach squeezes through the hiatus, an opening in the diaphragm through which the esophagus passes.

 and the hernias may be 

Hernias of Abdominal Wall 

Think of the abdomen as a bucket, 0r PAIL that contains the viscera. These are the four groups of hernias:

Pelvic hernias: obturator, perineal, sciatic

Anterior hernias: epigastric, incisional, Spigelian, supravesical,umbilical

Inguinal hernias: indirect, direct, femoral

Lumbar hernias: inferior lumbar triangle (Petit), superior lumbar triangle (Grynfelt)

medinotes :)

FAGET SIGN

The Faget sign — sometimes called sphygmothermic dissociation — is the unusual pairing of fever with bradicardiya (slow pulse). (Fever is usually accompanied by tachycardia,  (rapid pulse), 

Faget sign is often seen in:

• yellow fever
• typhoid fever
• tularemia
• brucellosisi
• colorado tick fever
• Some phnemonias - legionella pneumonia and mycoplasma pneumonia
• Drug Fever (e.g. Beta-Blockers,^[3] known as the Beta-Faget sign)

LIEBERMEISTER RULE

hai guys!!

Liebermeister's rule -
concerns the increment ratio between an adult individual's cardiac frequency and temperature when in fever.

Each Celsius grade of body temperature increment corresponds to an 8 beats per minute increase in cardiac frequency.

An exception to this rule by creating a relative bradycardia is known as Faget sign (pulse-temperature dissociation)

medinotes!:)